IL-8→Interleukin-8→Vascular Endothelial Growth Factor A→JunD

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 11208853(Interleukin-8): Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival.

  CONCLUSION : Our data suggest that the angiogenic serum factors VEGF , bFGF , and IL-8 are useful predictive markers for overall and progression-free survival in melanoma patients.

• 15519527(Vascular Endothelial Growth Factor A): Different signalling pathways regulate VEGF and IL-8 expression in breast cancer: implications for therapy.

  Elevated expression of pro-angiogenic cytokines is associated with aggressive tumor growth and decreased survival of patients with breast cancer.

• 12820962(JunD): JunD mediates survival signaling by the JNK signal transduction pathway.

  However , JNK is also capable of signaling cell survival.