IL-8→Interferon-gamma→Interleukin-12→STAT1

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 2491786(Interferon-gamma): Elevated serum interferon levels in patients with Bell's palsy.

  The serum IFN-gamma levels were analyzed by radioimmunoassay in 32 of the patients : the IFN-gamma levels were alike in the acute and convalescent phases and the control subjects.

• 8648121(Interleukin-12): Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

  Infections of NK and T cell-deficient mice demonstrated that virus-induced IFN-alphabeta , TNF , and IL-12 , but not IFN-gamma , were produced independently of these populations , and that IL-12 production occurred in the absence of detectable IFN-gamma.

• 19728309(STAT1): PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.

  Similarly , IFN-gamma production induced by polyI : C plus IL-12 was reduced in NK cells isolated from IFNAR1 (- / -) compared with WT mice.