IL-8→Interleukin-10→Interleukin-6→CREB

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  In a cross-sectional study , the geometric mean of IL-8 level was significantly higher in the patients with A-T (P (.0001).

• 18479302(Interleukin-10): Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma.

  Consequently , patients with elevated IL-6 , IL-8 and IL-10 levels prior to treatment had a lower response to therapy.

• 19956602(Interleukin-6): Lymphoma and myeloma cell resistance to cytotoxic agents and ionizing radiations is not affected by exposure to anti-IL-6 antibody.

  BACKGROUND : Production of high levels of IL-6 is often correlated with resistance to cytotoxics or ionizing radiations , in cancer cell lines as in various cancer patients.

• 19875824(CREB): Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells.

  Although ionizing radiation induces a loss of proliferative capacity as well as cell death by apoptosis and necrosis , cells can oppose the damaging effects by activating survival signal pathways.