IL-8→Vascular Endothelial Growth Factor A→Tumor Necrosis Factor-alpha→STAT1

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 9231925(Vascular Endothelial Growth Factor A): Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients.

  For 19 treated patients , consecutive serum samples were analyzed.

• 18778497(Tumor Necrosis Factor-alpha): Significant alterations of serum cytokine levels in patients with Peyronie's disease.

  RESULTS : Mean cytokine levels in serum from patients were increased for TGF-beta1 and IFN-gamma compared to healthy controls.

• 20016942(STAT1): IFN-gamma down-regulates TGF-beta1-induced IgA expression through Stat1 and p300 signaling.

  We investigated the effect of IFN-gamma on TGF-beta1-induced IgA isotype expression.