IL-8→Vascular Endothelial Growth Factor A→Vascular Endothelial Growth Factor A→CREB

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 9231925(Vascular Endothelial Growth Factor A): Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients.

  Fifty-eight per cent of the patients with progressive disease during treatment compared with 15 % of the patients showing response to treatment (chi-squared test P (0.05) had elevated bFGF and/or VEGF serum levels.

• 10094946(Vascular Endothelial Growth Factor A): Vascular endothelial growth factor production in peritoneal macrophages of cirrhotic patients: regulation by cytokines and bacterial lipopolysaccharide.

  This study assessed whether peritoneal macrophages of cirrhotic patients can be up-regulated to produce VEGF under proper stimulatory conditions.

• 20067582(CREB): CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.

  VEGF-A also up-regulated VEGFR-2 and phosphorylated CREB , and protected H19-7 neurons and b. End3 endothelial cells against OGD.