IL-8→Interleukin-10→Interleukin-6→c-jun

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 18479302(Interleukin-10): Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma.

  Worse survival was also confirmed in patients with combined elevated pretreatment serum levels of IL-6 , IL-8 and IL-10 (none , one , two or three elevated).

• 15170913(Interleukin-6): Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor.

  CONCLUSION : MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase-independent pathways.

• 20121928(c-jun): c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.

  Epidermal growth factor (EGF) - induced cyclooxygenase-2 (COX-2) expression in squamous cell carcinomas is mediated through the extracellular signal-regulated kinase 1/2 and p38 pathways.