IL-8→Interferon-gamma→Recombinant Proteins→STAT1

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Serum interleukin (IL) -8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T.

• 2491786(Interferon-gamma): Elevated serum interferon levels in patients with Bell's palsy.

  Serum samples from 91 patients were assayed for antiviral activity using a bioassay.

• 10090400(Recombinant Proteins): Oromucosal interferon therapy: marked antiviral and antitumor activity.

  No antiviral activity was observed after oromucosal administration of murine IFN-alpha/beta in animals in which the IFN receptor had been inactivated by homologous recombination.

• 20504369(STAT1): Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke.

  Because airway epithelial cell responses to type II interferon (IFN) are critical in regulation of defense against many respiratory viral infections , we hypothesized that cigarette smoke has inhibitory effects on IFN-gamma-dependent antiviral mechanisms in epithelial cells in the airway.