IL-8→Receptor, erbB-2→Tyrosine→c-jun

• 20171651(IL-8): Elevated serum IL-8 levels in ataxia telangiectasia.

  Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

• 15138574(Receptor, erbB-2): The course of serum HER-2/neu levels as an independent prognostic factor for survival in metastatic breast cancer.

  Patients with continuously elevated serum HER-2 / neu levels had a significantly poorer survival after disease recurrence compared to patients with continuously or temporarily non-elevated serum HER-2 / neu values (log-rank test : p (0.001).

• 19360341(Tyrosine): Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.

  Activation of HER-2 / neu leads to multiple signalling cascades and plays a vital role in cell survival and growth.

• 20516211(c-jun): Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.

  The AP-1 transcription factor c-Jun is phosphorylated at multiple sites within its transactivation domain by the JNKs , and c-Jun phosphorylation is required for JNK-induced neurotoxicity.