TNF-alpha→myxovirus resistance proteins→California→BRCA1

• 20187705(TNF-alpha): IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE.

  Deficiencies in the recognition and engulfment of apoptotic cells have been reported in patients with systemic lupus erythematosus (SLE).

• 19748832(myxovirus resistance proteins): Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

  Breakdown of immune homeostasis contributes to the pathogenesis of systemic lupus erythematosus (SLE).

• 18386139(California): Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California.

  SLE patients had higher risks of vagina/vulva (SIR = 3.27 , 95 % CI = 2.41 -4.31) and liver cancers (SIR = 2.70 , 95 % CI = 1.54 -4.24).

• 12237281(BRCA1): Cancer Incidence in BRCA1 mutation carriers.

  To evaluate the risks of other cancers in BRCA1 mutation carriers , we conducted a cohort study of 11 847 individuals from 699 families segregating a BRCA1 mutation that were ascertained in 30 centers across Europe and North America.