TNF-alpha→Tumor Necrosis Factor-alpha→Superoxide Dismutase→c-jun

• 20359615(TNF-alpha): [Interstitial lung disease and anti-TNF-alpha therapy in rheumatoid arthritis: Two different patterns?]

  We report two cases of women treated with anti-TNF-alpha therapy for RA who both developed exacerbations of their preexisting ILD thought to be due to the treatment.

• 18565243(Tumor Necrosis Factor-alpha): Peripheral blood lymphocytes from patients with rheumatoid arthritis are differentially sensitive to apoptosis induced by anti-tumour necrosis factor-alpha therapy.

  Based on these data , it would be of interest to further study the interindividual variations of sensitivity to apoptosis induced by TNF alpha inhibitors in relation to treatment efficacy or resistance observed in RA patients.

• 8885330(Superoxide Dismutase): TNF alpha alters mitochondrial membrane potential in L929 but not in TNF alpha-resistant L929.12 cells: relationship with the expression of stress proteins, annexin 1 and superoxide dismutase activity.

  Using the lipophilic dye JC-1 to determine mitochondrial membrane potential , we showed that TNF alpha induces time-dependent alterations in mitochondrial membrane potential in L929 cells but not in the TNF alpha-resistant L929.

• 20139358(c-jun): Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis.

  Fluorescence-activated cell sorting analysis revealed that oxLDL increased mitochondrial superoxide production by 1.88 + / -0.19 - fold and mitochondrial membrane potential by 18 %.