IFN-gamma→Amyloid beta-Protein→Amyloid Precursor Protein Secretases→JunD

• 20368278(IFN-gamma): IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.

  Reactive gliosis surrounding amyloid beta (Abeta) plaques is an early feature of Alzheimer 's disease pathogenesis and has been postulated to represent activation of the innate immune system in an apparently ineffective attempt to clear or neutralize Abeta aggregates.

• 11016545(Amyloid beta-Protein): Regulation of amyloid precursor protein processing by Abeta in human glioma cells.

  A balance in APP metabolism may influence the outcome between toxicity and protection to central nervous system (CNS) neurons in Alzheimer 's disease.

• 15592359(Amyloid Precursor Protein Secretases): Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.

  GeneChip analysis and in vitro kinase assays revealed potent APP-dependent repression of c-Jun , its target gene SPARC and reduced basal c-Jun N-terminal kinase (JNK) activity in PC12 cells overexpressing APP.

• 15927205(JunD): Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma.

  To study the role of c-Jun N-terminal kinase (JNK) and its relation to transcription factor AP-1 and Jun family proteins in hepatocellular carcinoma (HCC) with or without hepatitis B virus (HBV) infection.