IL-1 beta→NF-kappa B→NF-kappa B→BRCA1

• 20396780(IL-1+beta): Effect of interleukin-1beta on the behavior of rats during mild stress in the open-field test.

  We conclude that interleukin-1beta abolishes the behavioral differences between active and passive specimens in the open field.

• 14581482(NF-kappa B): Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.

  Thus , although NF-kappaB activation was essential for interleukin-1beta induction of each of the proteins studied , gene expression was differentially regulated by ERK and by the duration of NF-kappaB activation.

• 9618523(NF-kappa B): NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.

  In this report , we demonstrate that conditioned medium (CM) from estrogen receptor (ER) - negative but not ER-positive breast cancer cells induces NF-kappaB in fibroblasts.

• 20346095(BRCA1): Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

  There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer.