TNF-alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→ATF2

• 20422754(TNF-alpha): [Impact of TNF-alpha gene polymorphism, development of atherogenic dyslipidemia and risk of atherosclerosis]

  Triglyceride levels in the GA+AA group were significantly (more than 3-fold) higher than in GG genotype patients.

• 15533517(Tumor Necrosis Factor-alpha): Association of bladder tumors and GA genotype of -308 nucleotide in tumor necrosis factor-alpha promoter with greater tumor necrosis factor-alpha expression.

  The TNF-alpha serum levels of the GA genotype were significantly greater than those of the GG genotype for both patients and controls.

• 15265685(Tumor Necrosis Factor-alpha): Involvement of iNOS-dependent NO production in the stimulation of osteoclast survival by TNF-alpha.

  We have previously shown that tumor necrosis factor alpha (TNF-alpha) promotes the survival of differentiated osteoclasts.

• 12130576(ATF2): p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function.

  However , SB203580 inhibited neither the survival nor dentine-resorption activity of osteoclasts induced by RANKL.