TNF-alpha→Interleukin-1beta→Interleukin-8→c-jun

• 20422754(TNF-alpha): [Impact of TNF-alpha gene polymorphism, development of atherogenic dyslipidemia and risk of atherosclerosis]

  In this 5-year prospective cohort study , 92 clinically healthy subjects (42 men and 50 women) were screened for G-308A polymorphism of the TNF-alpha gene.

• 18225559(Interleukin-1beta): The interleukin-1 beta gene polymorphism +3953 C/T is not associated with risk for oral cancer.

  PATIENTS AND METHODS : The +3953 C/T polymorphism was examined in DNA samples of 108 patients with oral squamous cell carcinoma and 156 healthy controls.

• 17174061(Interleukin-8): The interleukin-8 (-251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma.

  METHODS : The IL-8 (-251 A/T) polymorphism , which influences IL-8 gene expression , was evaluated by restriction fragment length polymorphism analysis in DNA samples of 158 German and Greek patients with oral squamous cell carcinoma and 156 healthy controls of equivalent sex , ethnicity and age.

• 20121928(c-jun): c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.

  Examination of a basaloid and a conventional oral squamous cell carcinoma cell line revealed that inhibition of c-Jun N-terminal kinase (JNK) with SP600125 increased EGF-induced (but not basal) COX-2 transcription 1.5 -1.9 - fold in extracellular signal-regulated kinase 1/2 and p38 pathway-dependent manners.