TNF-alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→NF-KB

• 20447852(TNF-alpha): Pregnancy during TNFalpha antagonist therapy: beware the rifampin-oral contraceptive interaction. Report of two cases.

  We report two cases of pregnancy in patients taking TNFalpha antagonists for chronic inflammatory joint disease.

• 18240230(Tumor Necrosis Factor-alpha): Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists.

  METHODS : A standardized stress task was administered to 3 groups of subjects : RA patients taking TNFalpha antagonists , RA patients not taking such medications , and healthy controls.

• 19773288(Tumor Necrosis Factor-alpha): Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis.

  METHODS : Two complementary approaches were taken : in the first ` in vitro ' approach monocyte-derived DC from healthy donors were matured with lipopolysaccharide and treated with TNFalpha antagonists in vitro for 48 h. In the second ` ex vivo ' approach monocyte-derived DC were generated from RA patients before and 8-12 weeks into anti-TNFalpha treatment.

• 20164431(NF-KB): Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation.

  In this study , we sought to investigate the effect of ischemia on DC activity in vitro.