IFN-gamma→interferon gamma receptor→Trans-Activators→STAT2

• 20500698(IFN-gamma): Analysis of functional SNP in ifng/ifngr1 in Chinese Han population with tuberculosis.

  We continued to search for other functional single nucleotide polymorphisms (SNP) and investigated their influence on patients with tuberculosis in the Chinese population.

• 15207788(interferon gamma receptor): Interferon-gamma receptor 1 promoter polymorphisms: population distribution and functional implications.

  Six different single nucleotide polymorphisms (SNPs) were detected in the IFNGR1 MPR.

• 11872950(Trans-Activators): Analysis of the sequence polymorphism within class II transactivator gene promoters.

  Thus the differences in the level of MHC class II expression , which are observed between individuals , stem for the polymorphisms of the MHC class II promoters themselves.

• 11952149(STAT2): Interferon type I downregulates human parainfluenza virus type 3-induced major histocompatibility complex class II expression.

  Here we report that IFN-alpha/beta also inhibits the CIITA-independent expression of HPIV3-induced MHC class II.