TNF-alpha→NF-kappa B→Aspartate Aminotransferases→Interleukin-12→ATF2

• 20575400(TNF-alpha): [Sheshiliuhuang decoction on cytokines in patients with urinary tract infection]

  At the end of the treatment , serum levels of IL-6 and TNF-alpha in the treatment group were significantly decreased compared with the before treatment (P (0.01) and those did in the control group (P (0.01).

• 19208516(NF-kappa B): Urinary trypsin inhibitor attenuates hepatic ischemia-reperfusion injury by reducing nuclear factor-kappa B activation.

  Compared with the control group , the UTI treatment groups showed significantly lower serum alanine aminotransferase and aspartate aminotransferase levels , decreased myeloperoxidase activity , and reduced NF-kappaB activation.

• 10353542(Aspartate Aminotransferases): Effects of immunomodulation with interferon-gamma on hepatic ischemia-reperfusion injury.

  Pretreatment with low dose IFN-gamma augmented injury as measured by histology , aminotransferase concentrations , and myeloperoxidase activity.

• 10228031(Interleukin-12): Ischemia/reperfusion-induced IFN-gamma up-regulation: involvement of IL-12 and IL-18.

  IFN-gamma and IL-12 mRNA are subsequently up-regulated at day 6 following ischemia.

• 16724115(ATF2): Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.

  In vivo , the same factors bind to the unmethylated IFN-gamma promoter in T helper type 1 (TH1) cells but not the methylated IFN-gamma promoter in TH2 cells.