TNF-alpha→Tumor Necrosis Factor-alpha→BRCA1

• 20667082(TNF-alpha): The effects of a muscle resistance program on the functional capacity, knee extensor muscle strength and plasma levels of IL-6 and TNF-alpha in pre-frail elderly women: a randomized crossover clinical trial--a study protocol.

  The purpose of this study will be verified the effect of a muscle-strengthening program with load during a ten-week period in pre-frail elderly women with attention to the following outcomes : (1) plasma levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) , (2) functional capacity and (3) knee extensor muscle strength.

• 11156963(Tumor Necrosis Factor-alpha): Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans.

  Both TNF-alpha mRNA and protein levels were elevated in skeletal muscle from frail elderly (81 + / -1 year) as compared to healthy young (23 + / -1 year) men and women.

• 14572152(BRCA1): Defect of tumour necrosis factor-alpha (TNF-alpha) production and TNF-alpha-induced ICAM-1-expression in BRCA1 mutations carriers.

  RESULTS : We report that monocytes derived from healthy women with various germline mutations of BRCA1 had significantly decreased spontaneous (p = 0.03) and LPS-induced (p (0.001) production of TNF-alpha , as compared to monocytes derived from healthy age-matched control females.