It has been reported that the dimeric isoform of the enzyme pyruvate kinase M2 was overexpressed in various solid tumor cells.
Compared to normal tissues all tumors investigated so far and especially those with a metastatic potential overexpress an isoenzyme of the pyruvate kinase , the pyruvate kinase type tumor M2 (TU M2-PK).
Tumor M2-PK is an isoform of the glycolytic enzyme pyruvate kinase.
The aim of this study was to determine pyruvate kinase activation and lipid peroxidation after hepatic ischemia.
To investigate the protective effect and mechanism of alanyl-glutamine dipeptide (Ala-Gln) against hepatic ischemia-reperfusion injury in rats.