glutamine→Glutamine→pyruvate kinase

• 16954343(glutamine): Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery.

  On the other hand , the oral and intraperitoneal administration of alanine (100 mg/kg) or glutamine (100 mg/kg) accelerates glucose recovery.

• 11378667(Glutamine): Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia.

  The IN group showed higher (P (0.05) hepatic glucose production from glycerol , L-alanine and L-glutamine and higher (P (0.05) production of L-lactate , pyruvate and urea from L-alanine and L-glutamine.

• 14300524(pyruvate kinase): INSULIN: INDUCER OF PYRUVATE KINASE.

  Insulin treatment induced new synthesis of pyruvate kinase which was prevented by injection of ethionine and actinomycin D. The evidence indicated that the increased pyruvate kinase activity induced by inisulin entails at a certain stage a stimulation of the synthesis of certain RNA species relevant to the production of this enzyme.