pyruvate kinase→Riboflavin→Pyruvate Kinase→glutamine

• 17127778(pyruvate kinase): Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.

  It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.

• 963898(Riboflavin): Effect of riboflavin treatment on human red cell pyruvate kinase deficiency.

  The effect of riboflavin on six patients with hemolytic anemia due to hereditary pyruvate kinase deficiency was studied.

• 1159538(Pyruvate Kinase): Increased activity of pyruvate kinase in plasma of vitamin E-deficient rats.

  The activity of pyruvate kinase in plasma of 1-month-old male rats fed a vitamin E-deficient diet for 4 months increased 8.5-fold over that of 45 ppm vitamin E-supplemented animals.

• 9107629(glutamine): Dietary L-glutamine does not improve lymphocyte metabolism or function in exercise-trained rats.

  To determine the effects of low intensity regular exercise and dietary glutamine supplementation on plasma glutamine concentrations , lymphocyte metabolism , and immune function , male (278 + / - 5 g) and female (182 + / - 1 g) Sprague-Dawley Buffalo rats were fed nutritionally complete casein-based semi-purified diets + / - 2 % w/w glutamine.