Pyruvate kinase (PK) deficiency is asymptomatic in heterozygotes , but it can lead in homozygous neonates to a severe neonatal hemolysis , sometimes life-threatening.
In kidney medulla of rabbits with alloxan diabetes the pyruvate kinase activity was increased by 39 % as compared with control animals.
The hepatic pyruvate kinase activity markedly decreased when rats were made diabetic by alloxan injection.
To evaluate the effects of glutamine (L-Gln) or whey-protein supplementation on CD4 + and CD8 + lymphocytes in alloxan-induced diabetic rats.