Red blood cell pyruvate kinase (R-PK) deficiency is the most common glycolytic enzyme defect associated with hereditary non-spherocytic hemolytic anemia.
Two patients with non-spherocytic hemolytic anemia were found to have elevated red blood cell pyruvate kinase activities commensurate with the decreased mean red cell age , but the residual pyruvate kinase had marked kinetic abnormalities.
The hepatic pyruvate kinase activity markedly decreased when rats were made diabetic by alloxan injection.
To evaluate the effects of glutamine (L-Gln) or whey-protein supplementation on CD4 + and CD8 + lymphocytes in alloxan-induced diabetic rats.