The dimeric M2-isoform of pyruvate kinase (M2-PK) has been reported to be elevated in fecal specimens from colorectal cancer (CA) patients , but its role in IBD is unknown.
Compared to normal tissues all tumors investigated so far and especially those with a metastatic potential overexpress an isoenzyme of the pyruvate kinase , the pyruvate kinase type tumor M2 (TU M2-PK).
Recently , a high validity correlation of the tumor M2 pyruvate kinase (Tu M2-PK) isoenzyme in comparison to standard tumor markers has been demonstrated in solid tumors.
Heterogeneity also existed in isozyme composition of pyruvate kinase.
M-isozyme pyruvate kinase activity proved to be elevated in the liver of rats with hepatoma induced by p-dimethylaminoazobenzene.
To evaluate the in vivo effect of glutamine on cobalt-generated oxidative stress and (HO-1) induction in rat liver.