Tumor M2-pyruvate kinase , a tumor-associated dimeric form of enzyme pyruvate kinase , is commonly elevated in pancreatic cancers.
Recently , a high validity correlation of the tumor M2 pyruvate kinase (Tu M2-PK) isoenzyme in comparison to standard tumor markers has been demonstrated in solid tumors.
Heterogeneity also existed in isozyme composition of pyruvate kinase.
M-isozyme pyruvate kinase activity proved to be elevated in the liver of rats with hepatoma induced by p-dimethylaminoazobenzene.
To evaluate the in vivo effect of glutamine on cobalt-generated oxidative stress and (HO-1) induction in rat liver.