pyruvate kinase→Pyruvate Kinase→Glucose→glutamine

• 17632316(pyruvate kinase): Tumor M2-pyruvate kinase as tumor marker in exocrine pancreatic cancer a meta-analysis.

  Tumor M2-pyruvate kinase , a tumor-associated dimeric form of enzyme pyruvate kinase , is commonly elevated in pancreatic cancers.

• 15162541(Pyruvate Kinase): Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls.

  To achieve this , tumor cells generally overexpress a special glycolytic isoenzyme , termed pyruvate kinase type M (2).

• 9409743(Glucose): Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1.

  Replacement of glucose by pyruvate in the culture medium lowers glycolytic enzyme activity and prevents proliferation.

• 18060527(glutamine): Glutamine enhances glucose-induced mesangial cell proliferation.

  Glutamine in a high glucose (HG) environment increased cell proliferation in a dose-dependent manner.