pyruvate kinase→Pyruvate Kinase→glutamine

• 17784868(pyruvate kinase): Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention.

  A dimeric form of pyruvate kinase isoenzyme (tumor M2-PK) is predominantly found in highly proliferating cells.

• 15588442(Pyruvate Kinase): Plasma concentrations of tumour dimeric pyruvate kinase are increased in patients with chronic cardiac failure.

  The aim of the study was to assess the effect of chronic cardiac failure (CCF) on circulating plasma concentrations of tumor metabolic marker dimeric pyruvate kinase type M2 (M2-PK).

• 2867848(glutamine): Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure.

  Intravenous infusion of L-glutamic acid results in the augmentation of the cardiac output and an improvement of the circulation in patients with postoperative cardiac failure.