T. M. Murali
Dept. of Computer Science
murali at cs dot vt dot edu
(540) 231-8534 (phone)
432 Data and Decision Sciences Building (office address)
1160 Torgersen Hall (mailing address)
620 Drillfield Drive (mailing address)
Blacksburg, VA 24061
I direct the Destination Area initiative on Pandemic Prediction and Prevention. We are a group of faculty members, staff, and students whose vision is to reach an an aspirational destination: A world where we accurately foresee pandemics and proactively minimize their impact. We seek to reach this goal by forecasting and controlling future viral pandemics. We will address the grand challenge of uncovering the rules of life that underly virus-host interactions through community-based and ethically grounded research.
I am also the associate director for the Computational Tissue Engineering interdisciplinary graduate education program. I am affiliated with the Interdisciplinary Ph.D. Program in Genetics, Bioinformatics, and Computational Biology.
I joined Virginia Tech in 2003 as an Assistant Professor. From 2001 to 2003, I was a Senior Research Associate in the Bioinformatics Programme at Boston University, where I worked with Simon Kasif. Before joining Boston University, I worked at Compaq's Cambridge Research Lab. Till July 1999, I was a post-doc in the Computer Science Department at Stanford University. I worked with Leo Guibas and Jean-Claude Latombe on problems arising in computational geometry, computer graphics, and robotics. In particular, I was working on the Tactical Mobile Robots project.
Before I came to Stanford, I was a Ph.D. student at the Department of Computer Science at Brown University. From July 1993 to August 1998, I was a visiting scholar at the Department of Computer Science at Duke University, where my advisor Jeff Vitter moved from Brown University. I was a member of the Center for Geometric Computing at Duke. Before I started my graduate studies at Brown in 1991, I spent four years at the Indian Institute of Technology, Madras (IITM) getting a Bachelor of Technology degree in Computer Science and Engineering. My last two years in high school were spent at the pride of Luz Circle, Vidya Mandir, Madras.
In my research, I focus on problems in computational systems biology. Currently, I am working in the area of cellular response networks and their building blocks (network legos), gene function prediction (GAIN, Art, MENGO), host-pathogen protein-protein interactions (prediction, landscape) biclustering algorithms and their applications (xMotif, visualisation, XcisClique, Arabidopsis CO2, RankGene), and conserved protein interaction modules (GraphHopper). I am also interested in the problem of identifying ligand migration pathways in proteins such as myoglobin. In previous research, I studied problems in computational geometry, especially those motivated by applications in computer graphics, robotics, and geographic information systems. In my Ph.D. thesis, I studied the problem of hidden-surface removal.