TOP RESULTS

(All stories are significant at pvalue:1.0E-10)

SFRP1 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
17465504	15293985	8	0.96	4	2.4559103636175204	8e-15	SFRP1→Histones→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
18322704	9521710	2	0.88	4	2.5403303516638718	1.92e-12	SFRP1→ADP Ribose Transferases→Bromodeoxyuridine→poly-ADP-ribose
19543515	11115148	4	0.92	4	2.5543077368904714	8e-15	SFRP1→Granulocyte-Macrophage Colony-Stimulating Factor→Vascular Endothelial Growth Factor A→poly-ADP-ribose
18322704	8038764	2	0.88	4	2.5977790166946093	1.0128e-11	SFRP1→ADP Ribose Transferases→Isoquinolines→poly-ADP-ribose
19543515	6262062	10	0.96	4	2.60535474100217	8e-15	SFRP1→Genome, Human→Receptors, Somatomedin→poly-ADP-ribose

IL-6 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
18488438	8835300	4	0.84	4	2.418971808715728	8e-15	IL-6→NAD→Histones→poly-ADP-ribose
19505765	6316953	8	0.96	4	2.5185173847205045	8e-15	IL-6→Nitric Oxide→Hydrogen Peroxide→poly-ADP-ribose
19535096	3000421	10	0.96	4	2.5903508058150697	8e-15	IL-6→L-Lactate Dehydrogenase→1-Naphthylamine→poly-ADP-ribose
18257779	11420111	10	0.96	4	2.5974830210341726	8e-15	IL-6→Matrix Metalloproteinase 1→Tumor Necrosis Factor-alpha→poly-ADP-ribose
19698145	7664532	8	0.92	4	2.5979001533336388	8e-15	IL-6→Intercellular Adhesion Molecule-1→NF-kappa B→poly-ADP-ribose
18767579	7628865	10	0.96	4	2.637173130143603	8e-15	IL-6→Poly(ADP-ribose) Polymerases→Apoptosis Inducing Factor→poly-ADP-ribose
19521107	11420111	2	0.84	5	3.267258045538456	4.32e-18	IL-6→p38 Mitogen-Activated Protein Kinases→Apoptosis Inducing Factor→poly-ADP-ribose
18282396	3000421	2	0.88	5	3.3056660254617647	1.0128e-15	IL-6→NF-kappa B→Interleukin-1→1-Naphthylamine→poly-ADP-ribose
18606685	8147870	2	0.9	5	3.4416734266132734	2.54016e-15	IL-6→Proteoglycans→Interleukin-1→NAD→poly-ADP-ribose
19166837	3000421	4	0.84	5	3.2254795859053065	1.6e-19	IL-6→Chemokine CCL2→Poly(ADP-ribose) Polymerases→1-Naphthylamine→poly-ADP-ribose

MCP1 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
20029451	228176	4	0.86	4	2.4610474278531647	8e-15	MCP1→Poly(ADP-ribose) Polymerases→NAD→poly-ADP-ribose
19008128	2939000	12	0.96	4	2.4640582379825076	8e-15	MCP1→Interleukin-1→Interleukin-1→poly-ADP-ribose
20029451	6299867	6	0.88	4	2.475699435575877	8e-15	MCP1→Poly(ADP-ribose) Polymerases→1-Naphthylamine→poly-ADP-ribose
18688800	20420408	8	0.92	4	2.5634483521421343	8e-15	MCP1→Intercellular Adhesion Molecule-1→NAD→poly-ADP-ribose
19755790	8080500	6	0.96	4	2.5719954859649374	8e-15	MCP1→Interleukin-1→Nitric Oxide→poly-ADP-ribose
19010691	3000421	8	0.96	4	2.5970141418986605	8e-15	MCP1→Interleukin-1→1-Naphthylamine→poly-ADP-ribose
19543212	11410739	8	0.96	3	2.634499715995291	8e-15	MCP1→Interleukin-6→poly-ADP-ribose
19582157	8080500	8	0.96	4	2.6551580792698064	8e-15	MCP1→Intercellular Adhesion Molecule-1→Intercellular Adhesion Molecule-1→poly-ADP-ribose
19118698	11403206	10	0.96	3	2.7690973241255845	8e-15	MCP1→Intercellular Adhesion Molecule-1→poly-ADP-ribose
18657091	11420111	10	0.9	4	2.55256829531121	8e-15	MCP1→Isoquinolines→NAD→poly-ADP-ribose

nicotinamide to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
16701870	11420111	10	0.92	4	2.432604055010533	8e-15	nicotinamide→Tumor Necrosis Factor-alpha→NF-kappa B→poly-ADP-ribose
11893912	7642516	4	0.88	4	2.4530285502557074	8e-15	nicotinamide→ADP Ribose Transferases→Superoxide Dismutase→poly-ADP-ribose
10509758	6309564	2	0.9	5	3.094632117522841	1.6e-19	nicotinamide→NAD→Macromolecular Substances→Protein-Serine-Threonine Kinases→poly-ADP-ribose
12868016	8835300	2	0.86	5	3.175734189479544	1.728e-17	nicotinamide→Transcription Factor AP-1→Niacinamide→Isoquinolines→poly-ADP-ribose
12701884	9193655	2	0.9	5	3.3324104508794345	5.632e-17	nicotinamide→NADPH Dehydrogenase→Nitric Oxide Synthase→Nitric Oxide Synthase→poly-ADP-ribose
12243084	6315616	4	0.9	5	3.3329367785022446	9.6e-19	nicotinamide→NAD→Nucleotidyltransferases→Niacinamide→poly-ADP-ribose
15686992	6322868	2	0.88	5	3.3759081671721374	1.6e-19	nicotinamide→Niacinamide→NAD→Glycoside Hydrolases→poly-ADP-ribose
12154146	7980541	2	0.9	5	3.3869348854866317	2.3872e-16	nicotinamide→Niacinamide→Glycoside Hydrolases→callose→poly-ADP-ribose
17395461	20092359	2	0.88	4	3.4829321440428704	4.8e-18	nicotinamide→Macromolecular Substances→Virulence Factors→poly-ADP-ribose
10839263	8755499	2	0.9	7	5.069882707713659	1.7152e-26	nicotinamide→Matrix Metalloproteinase 1→Mmp13 protein, rat→Chromosomal Proteins, Non-Histone→Poly(ADP-ribose) Polymerases→ADP Ribose Transferases→poly-ADP-ribose

IL-1+beta to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
19265174	11420111	2	0.8	4	2.328576694617427	8e-15	IL-1 beta→Isoquinolines→Vascular Endothelial Growth Factor A→poly-ADP-ribose
19096964	8080500	2	0.86	4	2.4022550665771014	8e-15	IL-1 beta→Leukocyte Elastase→NAD→poly-ADP-ribose
19265174	10623965	2	0.82	4	2.4027709612109245	1.6e-14	IL-1 beta→Isoquinolines→NAD→poly-ADP-ribose
18603357	3000421	4	0.88	4	2.509266832491483	8e-15	IL-1 beta→Antigens, CD28→Ki-67 Antigen→poly-ADP-ribose
18454664	8835300	2	0.88	4	2.5197027935817573	8.64e-13	IL-1 beta→Interleukin-1→Collagenases→poly-ADP-ribose
17196563	3000421	2	0.9	4	2.531919258560288	3.6e-13	IL-1 beta→Interleukin-1→Prolactin→poly-ADP-ribose
20458900	8147870	4	0.9	4	2.5688107816476875	1.6e-14	IL-1 beta→Tumor Necrosis Factor-alpha→1-Naphthylamine→poly-ADP-ribose
20206549	18619441	2	0.88	4	2.588547637451581	1.12e-13	IL-1 beta→Nitric Oxide Synthase Type III→Alanine→poly-ADP-ribose
19081643	9521710	8	0.96	4	2.68684870765594	7.2e-14	IL-1 beta→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→poly-ADP-ribose
19442158	3000421	6	0.92	4	2.4933979329226275	8e-15	IL-1 beta→Poly(ADP-ribose) Polymerases→Glycoside Hydrolases→poly-ADP-ribose

IL-13 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
12919086	3000421	2	0.84	4	2.463077194828318	1.12e-13	IL-13→Chemokines→1-Naphthylamine→poly-ADP-ribose
12424628	8080500	2	0.86	4	2.516095686056551	1.12e-13	IL-13→Interleukin-8→NAD→poly-ADP-ribose
12537753	165508	6	0.96	4	2.5247166192188066	3e-12	IL-13→Intercellular Adhesion Molecule-1→Nucleoside Diphosphate Sugars→poly-ADP-ribose
12483208	1280112	2	0.88	4	2.5496810938859173	3.92e-13	IL-13→Receptors, Cytokine→Tumor Necrosis Factor-alpha→poly-ADP-ribose
14734772	3000421	18	0.96	4	2.576872282798312	8e-15	IL-13→Cyclic ADP-Ribose→Histones→poly-ADP-ribose
15315330	18619441	2	0.88	4	2.582753864168514	2.56e-13	IL-13→Matrix Metalloproteinase 1→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
12897201	9334851	6	0.92	4	2.603012120365797	8e-15	IL-13→Antibodies, Monoclonal→Tumor Necrosis Factor-alpha→poly-ADP-ribose
18296657	15293985	2	0.92	4	2.6049832485658566	2.6448e-11	IL-13→Interleukin-13→Alanine→poly-ADP-ribose
15307936	228176	4	0.9	4	2.623907942526235	8e-15	IL-13→Somatomedins→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
11681489	6458707	8	0.9	4	2.352862778910732	8e-15	IL-13→Interleukin-10→Nucleoside Diphosphate Sugars→poly-ADP-ribose

IL-24 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
18376144	20420408	2	0.9	4	2.463551169477553	3.44e-13	IL-24→Tumor Suppressor Protein p53→Radiation-Sensitizing Agents→poly-ADP-ribose
20501829	15293985	4	0.92	4	2.574791752604279	8e-15	IL-24→Interleukins→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
18059175	11420111	2	0.9	4	2.6514068920942226	2.616e-12	IL-24→Morpholines→Cisplatin→poly-ADP-ribose
18468766	20420408	2	0.92	4	2.652563399151312	1.952e-12	IL-24→Tumor Suppressor Protein p53→Cladribine→poly-ADP-ribose
18281515	6325408	2	0.86	6	4.138575443423622	5.888e-21	IL-24→dihydroceramide→Tumor Suppressor Protein p53→NF-kappa B→NF-kappa B→poly-ADP-ribose

IL-1+alpha to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
16101131	11420111	4	0.88	4	2.4793408284944713	8e-15	IL-1 alpha→Poly(ADP-ribose) Polymerases→Antibodies, Antinuclear→poly-ADP-ribose
17204250	3158622	4	0.9	4	2.503470491325319	8e-15	IL-1 alpha→ADP Ribose Transferases→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
8608352	8080500	4	0.88	4	2.506266214589912	8e-15	IL-1 alpha→Alanine→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
7943416	11420111	20	0.98	4	2.5106057577314065	8e-15	IL-1 alpha→Tumor Necrosis Factor-alpha→NF-kappa B→poly-ADP-ribose
11883273	7533621	4	0.88	4	2.5139811023994048	8e-15	IL-1 alpha→Interleukin-6→Tumor Necrosis Factor-alpha→poly-ADP-ribose
10469303	11420111	6	0.92	4	2.522377912524763	8e-15	IL-1 alpha→Interleukin-1→Tumor Necrosis Factor-alpha→poly-ADP-ribose
10880243	9521710	20	0.96	4	2.5821685200766185	8e-15	IL-1 alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→poly-ADP-ribose
7524240	6262062	8	0.96	4	2.617226806453139	8e-15	IL-1 alpha→Antibodies, Monoclonal→Antibodies, Monoclonal→poly-ADP-ribose
8565056	240831	6	0.96	4	2.6723060308364603	8e-15	IL-1 alpha→Antibodies, Monoclonal→Bacterial Proteins→poly-ADP-ribose
12182845	16317386	2	0.86	3	3.2802450301942954	1.12e-18	IL-1 alpha→Carrageenan→poly-ADP-ribose

serpinB2 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
12841679	1549180	2	0.92	4	2.53145193099674	3.744e-12	serpinB2→coenzyme Q10→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
15075337	6309564	2	0.86	4	2.475025357762719	2.4e-14	serpinB2→Interleukin-1→Tumor Necrosis Factor-alpha→poly-ADP-ribose

IGF-1 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
18997009	15293985	6	0.96	4	2.4744524662496765	2.4e-14	IGF-1→Superoxide Dismutase→Amphetamines→poly-ADP-ribose
18464249	8835300	18	0.98	4	2.5062048157431436	8e-15	IGF-1→Receptors, Interleukin-1→Interleukin-1→poly-ADP-ribose
18059474	3000421	14	0.92	4	2.5103584385295847	8e-15	IGF-1→Poly(ADP-ribose) Polymerases→Histones→poly-ADP-ribose
17303558	6299867	10	0.96	4	2.512175800743132	8e-15	IGF-1→Glucose→Interleukin-1→poly-ADP-ribose
17187980	11672522	4	0.9	4	2.5383551791890744	8e-15	IGF-1→Phosphotyrosine→tyrphostin AG 1024→poly-ADP-ribose
19394223	12072379	4	0.9	4	2.5975331190432867	8e-15	IGF-1→Receptor, IGF Type 1→Glucagon→poly-ADP-ribose
20214459	2940104	10	0.96	4	2.6338508386156283	8e-15	IGF-1→Tumor Necrosis Factor-alpha→NAD→poly-ADP-ribose
17162432	11420111	16	0.92	4	2.666910759784578	8e-15	IGF-1→Pregnancy-Associated Plasma Protein-A→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
20045394	6237718	2	0.92	5	3.5827279102205543	8.96e-18	IGF-1→Dexamethasone→Phosphates→Bacterial Proteins→poly-ADP-ribose
16254703	11420111	2	0.84	6	3.8566917504517133	2.56e-22	IGF-1→Radiation-Protective Agents→Thalidomide→NF-kappa B→NF-kappa B→poly-ADP-ribose

CXCL1 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
17619015	3000421	2	0.84	4	2.431840943498112	1.2e-13	CXCL1→Phenyl Ethers→1-Naphthylamine→poly-ADP-ribose
15843053	3000421	4	0.9	4	2.489943280462599	1.2e-13	CXCL1→Poly(ADP-ribose) Polymerases→Histones→poly-ADP-ribose
15843053	8835300	4	0.9	4	2.509286011292927	8e-15	CXCL1→Poly(ADP-ribose) Polymerases→Isoquinolines→poly-ADP-ribose
11483765	7488045	6	0.88	4	2.5255597893384243	8e-15	CXCL1→Poly(ADP-ribose) Polymerases→Nucleoside Diphosphate Sugars→poly-ADP-ribose
15843053	6293541	4	0.9	4	2.5403424639120664	3.2e-14	CXCL1→Interleukin-6→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
15843053	228176	4	0.9	4	2.5764626605107392	1.6e-14	CXCL1→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
15967733	3000421	10	0.92	4	2.5791229089982894	8e-15	CXCL1→Poly(ADP-ribose) Polymerases→Histones→poly-ADP-ribose
15843053	11040421	6	0.92	4	2.5991356707520685	8e-15	CXCL1→Interleukin-6→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
15843053	18619441	6	0.92	4	2.609658878571825	8e-15	CXCL1→Poly(ADP-ribose) Polymerases→Transcription Factors→poly-ADP-ribose
10545642	6309564	20	0.96	4	2.722160075836667	8e-15	CXCL1→DDT→Tumor Necrosis Factor-alpha→poly-ADP-ribose

IFN-gamma to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
19095086	8080500	4	0.88	4	2.4351096150104663	8e-15	IFN-gamma→Peroxidase→Nitric Oxide Synthase→poly-ADP-ribose
19514843	3000421	6	0.9	4	2.495551176062051	8e-15	IFN-gamma→Caspase 3→1-Naphthylamine→poly-ADP-ribose
19203563	2940104	8	0.96	4	2.510027521980893	8e-15	IFN-gamma→Phenanthrenes→Dimethyl Sulfoxide→poly-ADP-ribose
19751227	8080500	16	0.96	4	2.541304201183682	8e-15	IFN-gamma→Tumor Necrosis Factor-alpha→Nitric Oxide→poly-ADP-ribose
19291858	7980541	8	0.96	4	2.5524614825751506	8e-15	IFN-gamma→Zymosan→Peroxidase→poly-ADP-ribose
19447514	6309564	4	0.9	4	2.559588834667083	8e-15	IFN-gamma→NF-kappa B→Tumor Necrosis Factor-alpha→poly-ADP-ribose
20226760	6299867	6	0.92	4	2.612662289196422	8e-15	IFN-gamma→Antibodies→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
20375612	15293985	4	0.92	4	2.6633312145061794	2.4e-14	IFN-gamma→Indicators and Reagents→ADP Ribose Transferases→poly-ADP-ribose
19659932	8755499	8	0.96	4	2.6992104195669158	8e-15	IFN-gamma→Interleukin-6→Interleukin-12→poly-ADP-ribose

MCP-2 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
10644541	6316953	12	0.98	4	2.5437419603771794	8e-15	MCP-2→Pentoxifylline→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
10644541	3158622	2	0.88	4	2.5644645181765524	3.584e-12	MCP-2→Nos2 protein, rat→Hydrogen Peroxide→poly-ADP-ribose
10644541	3000421	14	0.92	4	2.572999930584621	8e-15	MCP-2→Nos2 protein, rat→Nucleoside Diphosphate Sugars→poly-ADP-ribose
9119400	9417885	4	0.92	4	2.6199547900471005	3.7888e-11	MCP-2→Deoxyribonuclease I→Interferon-gamma→poly-ADP-ribose
12147625	8076634	12	0.98	4	2.632588579837271	2.4e-14	MCP-2→Chemokines→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
9119400	10570184	4	0.92	4	2.641993941552679	8e-15	MCP-2→Recombinant Proteins→Oligonucleotide Probes→poly-ADP-ribose
15826819	10504727	20	0.98	4	2.584097123391164	8e-15	MCP-2→Niacinamide→Peptide Fragments→poly-ADP-ribose

CD38 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
10233418	6322868	6	0.92	4	2.3620147660965167	8e-15	CD38→Cyclic ADP-Ribose→Cyclic ADP-Ribose→poly-ADP-ribose
11853403	15293985	6	0.9	4	2.5682661845987833	8e-15	CD38→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
19644143	1899803	4	0.9	4	2.5756288612854648	8e-15	CD38→Interferon-gamma, Recombinant→Interferon-gamma→poly-ADP-ribose
7690555	221495	2	0.86	5	3.1691054744626292	1.28e-18	CD38→Antigens, Differentiation→Antigens, Differentiation→Membrane Glycoproteins→poly-ADP-ribose
7690555	228176	2	0.86	5	3.289494059650208	2.944e-17	CD38→Antibodies, Monoclonal→Cyclic ADP-Ribose→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
8962429	228176	2	0.86	5	3.307228666644144	8e-18	CD38→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→Nucleotidyltransferases→poly-ADP-ribose
8962429	15293985	2	0.86	5	3.3477025006499437	3.36e-18	CD38→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→Nucleoside Diphosphate Sugars→poly-ADP-ribose
7690555	3036216	4	0.86	5	3.2151005924107405	1.6e-19	CD38→Antibodies, Monoclonal→Cyclic ADP-Ribose→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

IL-8 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
19719901	12581860	10	0.92	4	2.331942526397153	8e-15	IL-8→NF-kappa B→NF-kappa B→poly-ADP-ribose
19760951	3000421	10	0.96	4	2.4507745780227763	8e-15	IL-8→Ki-67 Antigen→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
19376162	2931521	8	0.96	4	2.48515564927831	8e-15	IL-8→Antigens, Differentiation, Myelomonocytic→Leptin→poly-ADP-ribose
19509619	11420111	4	0.9	4	2.486773609161878	8e-15	IL-8→Chemokine CCL2→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
19567206	6309564	2	0.86	4	2.5137784468925877	8e-15	IL-8→Niacinamide→Tumor Necrosis Factor-alpha→poly-ADP-ribose
19435412	11420111	2	0.9	4	2.5635572132822233	4.64e-13	IL-8→Glycyrrhetinic Acid→NAD→poly-ADP-ribose
18930835	15110462	6	0.96	4	2.5998758706517195	8e-15	IL-8→Adipocytes→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
20441516	6321175	4	0.92	4	2.61828215871574	3.04e-13	IL-8→Antigens, Differentiation→Niacinamide→poly-ADP-ribose
19587833	12581860	2	0.9	4	2.6455614604338704	2.88e-13	IL-8→CX3CL1 protein, human→NF-kappa B→poly-ADP-ribose
19041333	6299867	2	0.88	5	3.1545902108430335	1.92e-18	IL-8→Nitrogen Dioxide→Nitrogen Dioxide→Proinsulin→poly-ADP-ribose

MMP12 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
18619044	8080500	2	0.88	4	2.416830481380677	1.44e-13	MMP12→Tumor Necrosis Factor-alpha→NAD→poly-ADP-ribose
19731200	8080500	2	0.88	4	2.429433975759134	9.6e-14	MMP12→Interleukin-8→NAD→poly-ADP-ribose
12735638	1531861	4	0.88	4	2.4373556310071334	8e-15	MMP12→Interleukin-8→Nitric Oxide Synthase→poly-ADP-ribose
15987457	2940104	14	0.92	4	2.45609452910381	8e-15	MMP12→Poly(ADP-ribose) Polymerases→Dimethyl Sulfoxide→poly-ADP-ribose
19731200	6458707	4	0.9	4	2.4769445544500166	8e-15	MMP12→Interleukin-8→NAD→poly-ADP-ribose
19775099	8080500	4	0.9	4	2.5415033808690035	7.2e-14	MMP12→Isoquinolines→Nuclear Proteins→poly-ADP-ribose
16676616	8080500	2	0.88	4	2.591124751059029	2.8e-13	MMP12→Tumor Necrosis Factor-alpha→NAD→poly-ADP-ribose
15289103	20092359	10	0.96	3	2.69974730258514	8e-15	MMP12→Tumor Suppressor Protein p53→poly-ADP-ribose
19703773	3080986	4	0.88	5	3.3204396741281603	1.6e-19	MMP12→Matrix Metalloproteinase 1→Isoquinolines→Nuclear Proteins→poly-ADP-ribose

MMP-3 to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
18029177	8080500	4	0.88	4	2.5736910959357067	8e-15	MMP-3→Isoquinolines→Nuclear Proteins→poly-ADP-ribose
18029177	2531222	4	0.88	4	2.5802091117345616	8e-15	MMP-3→Isoquinolines→Nuclear Proteins→poly-ADP-ribose
17710450	20092359	2	0.82	3	3.1926680739778175	1.6e-19	MMP-3→Matrix Metalloproteinase 3→poly-ADP-ribose
18029177	8021488	6	0.9	5	3.243537634262852	1.6e-19	MMP-3→Isoquinolines→Nuclear Proteins→Thymine Nucleotides→poly-ADP-ribose
16603129	20092359	6	0.88	3	3.251623757985783	1.6e-19	MMP-3→Macromolecular Substances→poly-ADP-ribose
18029177	6317634	4	0.88	5	3.2630750137875904	1.6e-19	MMP-3→Isoquinolines→Nuclear Proteins→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
18029177	2150901	4	0.88	5	3.263393373118898	1.6e-19	MMP-3→Isoquinolines→Nuclear Proteins→Histones→poly-ADP-ribose
18029177	11854472	4	0.88	5	3.307917888296132	1.6e-19	MMP-3→MMP13 protein, human→Organic Chemicals→Carbazoles→poly-ADP-ribose

matrix+metalloproteinase to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
19556529	6458707	4	0.9	4	2.4485080320885855	8e-15	matrix metalloproteinase→Vascular Endothelial Growth Factor A→Isoquinolines→Isoquinolines→poly-ADP-ribose
20496198	9521710	4	0.9	4	2.5107878210734493	8e-15	matrix metalloproteinase→Niacinamide→ADP Ribose Transferases→poly-ADP-ribose
19595140	2931521	8	0.96	4	2.5407404535301565	8e-15	matrix metalloproteinase→Matrix Metalloproteinase 2→Catecholamines→poly-ADP-ribose
19464272	6314820	18	0.96	4	2.5460534269377644	8e-15	matrix metalloproteinase→Cytokines→14-3-3 Proteins→poly-ADP-ribose
20197064	3000421	8	0.96	4	2.5560936329946733	8e-15	matrix metalloproteinase→Antibodies, Monoclonal→Ki-67 Antigen→poly-ADP-ribose
20035078	3000421	4	0.88	4	2.5690745495944993	8e-15	matrix metalloproteinase→Dexamethasone→Niacinamide→poly-ADP-ribose
19466518	15110462	6	0.96	4	2.6956928709298618	8e-15	matrix metalloproteinase→Matrix Metalloproteinases→Tumor Necrosis Factor-alpha→poly-ADP-ribose
19466518	188648	6	0.96	4	2.699864908843436	8e-15	matrix metalloproteinase→Matrix Metalloproteinases→Tumor Necrosis Factor-alpha→poly-ADP-ribose
19216640	11420111	2	0.9	5	3.3624104376462975	2.6928e-15	matrix metalloproteinase→Transcription Factor AP-1→Matrix Metalloproteinase 2→Indoles→poly-ADP-ribose
19764560	228176	2	0.84	5	3.2298670381929337	9.2e-17	matrix metalloproteinase→Benzimidazoles→Poly(ADP-ribose) Polymerases→Progesterone→poly-ADP-ribose

stanniocalcin to poly-ADP-ribose

Top 10 least-cost stories:

Start	End	CliqueSize	Dist. Threshold	# Docs	PathCost	p-Value	Story
11861508	11420111	4	0.92	4	2.558997663463195	8e-15	stanniocalcin→Glucagon→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
9881653	12581860	4	0.88	4	2.5604257929134686	8e-15	stanniocalcin→Antibodies, Monoclonal→Interferon Type I→poly-ADP-ribose
1778405	8662833	2	0.92	4	2.5723484063221704	3.328e-12	stanniocalcin→Tetradecanoylphorbol Acetate→ICE-related protease 1→poly-ADP-ribose
18355956	8076634	2	0.9	4	2.6573166586657693	3.4744e-11	stanniocalcin→Glycoproteins→Poly(ADP-ribose) Polymerases→poly-ADP-ribose
19095074	9521710	6	0.96	4	2.7120672940577433	8.8e-14	stanniocalcin→Calcium→Peptide Fragments→poly-ADP-ribose
9027337	2452600	4	0.88	5	3.2923441331478926	1.6e-19	stanniocalcin→Neoplasm Proteins→Poly(ADP-ribose) Polymerases→NAD→poly-ADP-ribose