TOP RESULTS

(All stories are significant at pvalue:1.0E-10)



TNF-alpha to NF-KB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
204478522016443120.8642.50137118019976026.08e-13TNF-alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→NF-KB
201047502019548980.8853.16077153415309731.6e-19TNF-alpha→Interleukin-4→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→NF-KB

IL-8 to STAT2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
178696511280477180.9242.43560718904483948e-15IL-8→Interleukin-8→Interleukin-8→STAT2
187990951599482660.8842.44468301484836168e-15IL-8→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→STAT2
188370941280477180.9442.55869187334971538e-15IL-8→Interferon-gamma→Tumor Necrosis Factor-alpha→STAT2
179120131599482660.8842.62483964155200548e-15IL-8→NF-kappa B→Interleukin-8→STAT2
1755962811952149140.8853.01242448183596421.6e-19IL-8→Tumor Necrosis Factor-alpha→Interferon-gamma→Tumor Necrosis Factor-alpha→STAT2

IL-1+beta to NF-KB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
193177462047871720.8653.23447420797836666.030643e-13IL-1 beta→Interleukin-8→Cyclooxygenase 2→Interleukin-1→NF-KB
190969642041044420.8653.19784385887881232.14656e-14IL-1 beta→Tumor Necrosis Factor-alpha→NF-kappa B→NF-KB

IL-8 to STAT1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
198875381992959480.942.49681204275124646.4e-14IL-8→Interleukin-8→Interferon-gamma→STAT1
201716512001694260.8842.509511800180038e-15IL-8→Vascular Endothelial Growth Factor A→Tumor Necrosis Factor-alpha→STAT1
201716511688186440.8832.5471373005943558e-15IL-8→Interferon-gamma→Interleukin-12→STAT1
192597782038145360.9442.59084111923044353.84e-13IL-8→Tumor Necrosis Factor-alpha→Nitric Oxide→STAT1
201716512050436940.8642.48669654038526668e-15IL-8→Interferon-gamma→Recombinant Proteins→STAT1

IL-8 to ATF2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201716511134263880.9242.4238303551642188e-15IL-8→Interleukin-8→Interleukin-8→ATF2
201716511064043860.942.4549367622579878e-15IL-8→Interleukin-10→Interleukin-6→ATF2
190261251090374060.8842.52797564346223658e-15IL-8→Interleukin-1→Interleukin-1→ATF2
1988753810871852100.9242.54589945864695548e-15IL-8→NF-kappa B→NF-kappa B→ATF2
190261251139952320.8252.97428463185932263.192e-16IL-8→Interleukin 1 Receptor Antagonist Protein→Interleukin-1→Interleukin-1→ATF2

IL-1+beta to ATF3

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
200850441925457260.8842.47133068284767138e-15IL-1 beta→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→ATF3
2015180518755691100.9242.65003576402758338e-15IL-1 beta→lycopene→Receptors, TNF-Related Apoptosis-Inducing Ligand→ATF3
192745291986425820.9253.3202852204402326.940128e-11IL-1 beta→Interleukin-1→NF-kappa B→NF-kappa B→ATF3
191459081593371280.942.40247596348141728e-15IL-1 beta→Helicobacter pylori→Tumor Suppressor Protein p14ARF→ATF3

IL-1+beta to ATF2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
1986161512130576120.942.5161020844411998e-15IL-1 beta→Interleukin-6→Tumor Necrosis Factor-alpha→ATF2
201572061064043860.9242.51875060188670348e-15IL-1 beta→Interferon-gamma→p38 Mitogen-Activated Protein Kinases→ATF2
195559231672411560.953.37685179567795939.856e-16IL-1 beta→Interleukin-8→NF-kappa B→ATF2
190969641672411540.953.4415752359558749.025664e-14IL-1 beta→Tumor Necrosis Factor-alpha→NF-kappa B→Interleukin-6→ATF2
195559231220886560.953.4094452766531566.16e-17IL-1 beta→Interleukin-6→NF-kappa B→Interleukin-6→ATF2

TNF-alpha to BRCA1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
206670821457215240.8832.9363498008696035.89248e-15TNF-alpha→Tumor Necrosis Factor-alpha→BRCA1
202062581899075940.8643.10229759208976759.6e-19TNF-alpha→Cholesterol, Dietary→Fatty Acids→BRCA1
2018770512237281200.9243.1614305661477041.6e-19TNF-alpha→myxovirus resistance proteins→California→BRCA1
201182771907350540.8433.0348469959567381.6e-19TNF-alpha→resveratrol→BRCA1

IL-1+beta to BRCA1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
1923199814572152200.9432.4333775241560998e-15IL-1 beta→Tumor Necrosis Factor-alpha→BRCA1
2039678020346095100.942.5103941878573848e-15IL-1 beta→NF-kappa B→NF-kappa B→BRCA1
194458311043562860.933.0987180271620254e-18IL-1 beta→Transforming Growth Factor beta→Estrogens→BRCA1
192583282034609540.8853.3408081604950591.6e-19IL-1 beta→Caspase 1→NLRP3 protein, human→Genes, BRCA1→BRCA1

IL-1+beta to c-fos

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
1974798920111900180.9642.36516804318448868e-15IL-1 beta→Interleukin 1 Receptor Antagonist Protein→Cytokines→c-fos
2008504419336001100.9242.5135329924194348e-15IL-1 beta→Interleukin-1→p38 Mitogen-Activated Protein Kinases→c-fos
192745291972012240.8853.41690054378903348.8e-18IL-1 beta→Tumor Necrosis Factor-alpha→Interleukin-8→Interleukin-8→c-fos
192745292043247160.953.38630872472492063.04e-18IL-1 beta→Interleukin-1beta→Interleukin-8→c-fos

TNF-alpha to JunD

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
20644312142959760.9442.4743817850850947.2e-14TNF-alpha→Transcription Factor AP-1→Transcription Factors→JunD
201047501429597160.9842.52161949970712848e-15TNF-alpha→Actins→Transcription Factors→JunD
20378011893995760.942.5225140937699828e-15TNF-alpha→Tumor Necrosis Factor-alpha→Transcription Factor AP-1→JunD
201080151152650220.852.94938750866228853.29472e-15TNF-alpha→NF-kappa B→NF-kappa B→Tumor Necrosis Factor-alpha→JunD

IFN-gamma to JunD

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
20090849142959740.9242.51983855884110674.3344e-11IFN-gamma→Interleukin-8→Transcription Factor AP-1→JunD
197736771862501340.9232.60607951528422673.36e-13IFN-gamma→Chemokines→JunD
203682781592720520.8442.90384273485898261.517418e-11IFN-gamma→Amyloid beta-Protein→Amyloid Precursor Protein Secretases→JunD
20464128892258940.9242.5857438334632681.68e-13IFN-gamma→NF-kappa B→NF-kappa B→JunD

IFN-gamma to c-jun

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771996051420.8842.45473197192450386.88e-13IFN-gamma→Interleukin-6→Integrins→c-jun
197736772009336140.8842.55999881621398738e-15IFN-gamma→Interferon-gamma→Cytokines→c-jun

IL-8 to CREB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
198875382010384040.942.37933308048053951.992e-12IL-8→Interleukin-1→NF-kappa B→CREB
201716512006758260.942.44016648639771378e-15IL-8→Vascular Endothelial Growth Factor A→Vascular Endothelial Growth Factor A→CREB
201716511987582420.942.50172896985573031.344e-11IL-8→Interleukin-10→Interleukin-6→CREB
1772731820452968100.9242.63238507629114438e-15IL-8→Tumor Necrosis Factor-alpha→Interleukin-6→CREB

TNF-alpha to STAT2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201047501877458280.9242.38301071488356668e-15TNF-alpha→HLA Antigens→Interferon-alpha→STAT2
2068302314557668120.9442.4304480871133588e-15TNF-alpha→Tumor Necrosis Factor-alpha→NF-kappa B→STAT2
2013280615994826180.9442.6726060402983378e-15TNF-alpha→Tumor Necrosis Factor-alpha→Interleukin-5→STAT2

IL-1+beta to CREB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
187809531973101860.9442.63576765472837863.2896e-11IL-1 beta→Tumor Necrosis Factor-alpha→Serine→CREB
203674152006758220.8853.24480616207658021.971766e-12IL-1 beta→Collagen→Vascular Endothelial Growth Factor A→Vascular Endothelial Growth Factor A→CREB
19822562903751520.8832.47321381812598951.408e-12IL-1 beta→Dexamethasone→CREB

TNF-alpha to STAT1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201047501970124520.8242.38005534691575751.1664e-11TNF-alpha→Tumor Necrosis Factor-alpha→Plasminogen Activator Inhibitor 1→STAT1
204478521921793820.8832.57784878919011454.5312e-11TNF-alpha→Tumor Necrosis Factor-alpha→STAT1
206695591127835740.9232.5144085835840986.4e-13TNF-alpha→Tumor Necrosis Factor-alpha→STAT1

IL-1+beta to STAT2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
2008504416940534100.9242.40309423207274448e-15IL-1 beta→Interleukin-1→Interleukin-1→STAT2
196436861978196780.9442.5030802577522348e-15IL-1 beta→STAT1 protein, human→STAT1 protein, human→STAT2
188198991572381240.942.57910177479272258e-15IL-1 beta→Interleukin-6→Tumor Necrosis Factor-alpha→STAT2
187809531297243280.9242.59054678227444868e-15IL-1 beta→Intercellular Adhesion Molecule-1→Intercellular Adhesion Molecule-1→STAT2
2010407312804771140.9442.71148531184165138e-15IL-1 beta→Tumor Necrosis Factor-alpha→Interferon-alpha→Histocompatibility Antigens→STAT2

IL-1+beta to STAT1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
2008504417032168120.9232.4091316088826298e-15IL-1 beta→Interleukin-1→STAT1
188415291994002720.8653.2783148503619772.61696e-15IL-1 beta→Estrogens→Intercellular Adhesion Molecule-1→Interleukin-10→STAT1
201518051175246020.8253.77109813644102053.616e-20IL-1 beta→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→Interferon-gamma→STAT1

IFN-gamma to NF-KB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197390122043444820.942.5758625837295069.36e-13IFN-gamma→Interleukin-6→Interleukin-8→NF-KB

IL-8 to c-jun

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201716512012192880.9642.48945449640858162.36e-12IL-8→Interleukin-10→Interleukin-6→c-jun
1790342020028971100.9242.59581646494114267.2e-14IL-8→NF-kappa B→NF-kappa B→c-jun
179120132029900960.942.6185005179327511.44e-13IL-8→NF-kappa B→NF-kappa B→c-jun
191210631994411580.9442.73661561747837561.9864e-11IL-8→Interleukin-1beta→Tumor Necrosis Factor-alpha→c-jun
2017165120516211120.9242.5096589860481518e-15IL-8→Receptor, erbB-2→Tyrosine→c-jun

TNF-alpha to ATF3

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201100941852100640.8842.44554387769930244.0848e-11TNF-alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→ATF3
2005850512718878100.9442.57057947524662028e-15TNF-alpha→Interleukin-6→Interleukin-1→ATF3

TNF-alpha to ATF2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
202142211672411540.942.46589831005924731.2792e-11TNF-alpha→Ribavirin→Ribavirin→ATF2
205754001672411520.8453.03423633480922653.990077e-12TNF-alpha→NF-kappa B→Aspartate Aminotransferases→Interleukin-12→ATF2
2042275412130576140.9842.5369089052965482.4e-14TNF-alpha→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→ATF2

IFN-gamma to ATF3

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771852100640.9442.5580808144231332e-12IFN-gamma→Interleukin-10→Insulin-Like Growth Factor I→ATF3
197736771593371240.8842.58334194985694051.6e-14IFN-gamma→Interferon-gamma→Cytokines→ATF3
197390121593371280.9442.5927411221309644.48e-13IFN-gamma→Intercellular Adhesion Molecule-1→Intercellular Adhesion Molecule-1→ATF3
197736771925457220.8653.1398272059067022.301696e-13IFN-gamma→Toll-Like Receptors→Myeloid Differentiation Factor 88→Tumor Necrosis Factor-alpha→ATF3
203484971925457260.9242.5153613596043928e-15IFN-gamma→Tumor Necrosis Factor-alpha→HLA-DR Antigens→ATF3

IFN-gamma to ATF2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771137739020.8642.33546283198449031.408e-12IFN-gamma→Toll-Like Receptors→Interleukin-8→ATF2
197736771835422740.9242.4751416674280618e-15IFN-gamma→Interleukin-6→Interleukin-8→ATF2
197736771087185240.942.6097426091785981.152e-12IFN-gamma→Chemokines→Tumor Necrosis Factor-alpha→ATF2
196347121134263820.852.86039398600762064.176e-17IFN-gamma→Interferon-gamma→Interferon-gamma→Cytokines→ATF2
196574061672411580.8853.2168433799407651.6e-19IFN-gamma→Mucins→NF-kappa B→Interleukin-2→ATF2

IFN-gamma to BRCA1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
200206532034609580.942.579796653706678e-15IFN-gamma→Interleukin-8→Interleukin-8→BRCA1
1964316220346095140.942.60786853415872738e-15IFN-gamma→Tumor Necrosis Factor-alpha→NF-kappa B→BRCA1
200382032041786520.8653.2645070727469954.928e-17IFN-gamma→3' Untranslated Regions→Interferon-gamma→Receptor, Epidermal Growth Factor→BRCA1

IFN-gamma to c-fos

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771969397820.8842.4674771214747079.2232e-11IFN-gamma→Tumor Necrosis Factor-alpha→Interleukin-4→c-fos
197736771959540840.9242.54880083003325144.8e-13IFN-gamma→Interferon-gamma→Interleukin-1beta→c-fos
196347122043247120.8842.55322902899167265.472e-11IFN-gamma→Tuberculin→Tumor Necrosis Factor-alpha→c-fos
2002065320018662200.9642.65973402753932938e-15IFN-gamma→Tumor Necrosis Factor-alpha→Lymphocyte Function-Associated Antigen-1→c-fos

IL-8 to JunD

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
201716511282096220.8642.47594770313206254.8e-14IL-8→Interleukin-8→Vascular Endothelial Growth Factor A→JunD
17993253142959740.9242.55514771121041841.16e-12IL-8→Transforming Growth Factor beta→Transforming Growth Factors→JunD
184158268336952100.9242.55839608432746428e-15IL-8→Interleukin-4→Transcription Factors→JunD
19162161142959720.8853.26315267305060972.14656e-14IL-8→Transcription Factors→Epidermal Growth Factor→Transcription Factor AP-1→JunD
198875381152650280.942.29236710499360678e-15IL-8→Interleukin-8→Transcription Factor AP-1→JunD

IL-1+beta to JunD

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
20616033137374240.8832.4932827232369752e-13IL-1 beta→Macrophage Colony-Stimulating Factor→JunD
200602051461757160.9232.50612130313424244.8e-14IL-1 beta→Tumor Necrosis Factor-alpha→JunD
197997181282096280.964.2184254651429285.76e-23IL-1 beta→Interleukin-11→Interleukin-1beta→NF-kappa B→NF-kappa B→JunD
197598501592720520.8464.7055166295947671.2288e-25IL-1 beta→Interleukin-1→NF-kappa B→NF-kappa B→JNK Mitogen-Activated Protein Kinases→JunD
192745291152650220.8474.63708957337015451.536e-27IL-1 beta→Interleukin-1→Interleukin-1beta→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→JunD

IL-8 to NF-KB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
178696512019769020.8842.5540645642974332.952e-11IL-8→Interleukin-8→Interleukin-8→NF-KB
182121112047093840.9242.6422911724996671.44e-13IL-8→Interleukin-8→Interleukin-8→NF-KB
178968042059973580.9442.6694354973500752.64e-12IL-8→Interferon-gamma→FCGR2B protein, human→NF-KB
179120132020022960.942.49254170457412638e-15IL-8→Toll-Like Receptor 4→Cytokines→NF-KB

TNF-alpha to c-jun

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
203596152013935860.9442.443730151555338.392e-12TNF-alpha→Tumor Necrosis Factor-alpha→Superoxide Dismutase→c-jun
204227542012192840.9242.52442386242456478.88e-13TNF-alpha→Interleukin-1beta→Interleukin-8→c-jun
2012042920231445180.9442.68667459107216238e-15TNF-alpha→Insulin→Pravastatin→c-jun

IFN-gamma to STAT2

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771472222420.8832.2492228930044984.864e-12IFN-gamma→Interleukin-6→STAT2
197736771193238420.8842.34186403439130861.184e-11IFN-gamma→Interferon-gamma→Tryptophan→Tryptophan→STAT2
205006981195214920.8842.50248278219765651.5024e-11IFN-gamma→interferon gamma receptor→Trans-Activators→STAT2
199583021195214920.8642.51036427762044228.096e-12IFN-gamma→Interleukin-6→Interferons→STAT2
197736771975430720.8653.1861957208012091.72416e-15IFN-gamma→Toll-Like Receptors→Myeloid Differentiation Factor 88→Toll-Like Receptors→STAT2

IL-1+beta to c-jun

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
192745292012192840.942.50845068872844528.8e-14IL-1 beta→Interleukin-1beta→Epidermal Growth Factor→c-jun
201572061237527280.9232.6207752111290688e-15IL-1 beta→Interferon-gamma→c-jun
190969641064650340.943.4378824904447877.51424e-15IL-1 beta→Tumor Necrosis Factor-alpha→NF-kappa B→c-jun

IFN-gamma to STAT1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
197736771992413320.942.5742077287265633.1624e-11IFN-gamma→Interferon-gamma→Tumor Necrosis Factor-alpha→STAT1
197736771988912540.8842.61433250795216048e-15IFN-gamma→Interferon-gamma→Interleukin-10→STAT1

IFN-gamma to CREB

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
200382032006758240.9242.5835596830007113.52e-13IFN-gamma→Estrogen Receptor alpha→Vascular Endothelial Growth Factor A→CREB
2046412820103840200.9842.6318467761709191.224e-12IFN-gamma→Interferon-gamma→NF-kappa B→CREB
197736772003208140.9242.6441586905754131.92e-13IFN-gamma→Chemokines→Cyclooxygenase 2→CREB
1973901219644446120.9442.64909325353866181.6e-14IFN-gamma→Tumor Necrosis Factor-alpha→Tumor Necrosis Factor-alpha→CREB

IL-8 to BRCA1

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
17711487961983760.932.95731750591493376.4e-19IL-8→NF-kappa B→BRCA1
1847818418030615120.9433.0843588586453771.6e-19IL-8→Hypoxia-Inducible Factor 1→BRCA1
185351612034609540.8653.25717801443576341.6e-19IL-8→Dexamethasone→Fas Ligand Protein→Receptors, Estrogen→BRCA1
184158261509530740.8442.98755981667237161.6e-19IL-8→Smoke→Contraceptive Agents, Female→BRCA1

IL-8 to c-fos

Top 10 least-cost stories:
StartEndCliqueSizeDist. Threshold# DocsPathCostp-ValueStory
188370941928543620.8653.24254836439889263.653414e-13IL-8→Tumor Necrosis Factor-alpha→NF-kappa B→NF-kappa B→c-fos